- 阅读次数:
- 发布时间:2023-12-28
个人简介
孙巧,博士,校聘副教授
联系方式
办公地点:尚德楼A2-206
电子邮箱:sun_qiao@njtech.edu.cn
教育背景
2006.09-2010.06:四川大学,药学专业,理学学士
2010.09-2013.07:中国科学院大学,药物化学专业,理学硕士
2015.08-2019.12:新加坡南洋理工大学,有机化学专业,理学博士
工作经历
2015.08-2019.12:新加坡南洋理工大学,助教、研究助理
2019.11-2020.04:新加坡国立大学,博士后
2020.07-2020.10:中国科学院福建物质结构研究所,访问学者
2020.11-2022.10:药明康德上海合全药业股份有限公司,高级研究员
2023.02-至今:万博体育bet 食品与轻工学院,校聘副教授
教学工作
主讲本科生课程《高分子化学》,指导本科生毕业论文。
科学研究
主要研究方向为:1)廉价金属、光、电、酶绿色催化过程开发和研究;2)高通量筛选技术在新型染料、助剂化学品、食品添加剂、各类香精香料和关键药物中间体结构筛选和工艺放大中的研究和应用; 3)生物活性化合物的设计、合成及活性评价。主持万博体育bet 科研启动金项目;参与2023年中国石化“种子计划”课题(在研, 2024-2026);作为课题骨干参与新加坡教育学术研究基金、新加坡科学技术和研究局(A*STAR)多项研究项目(MOE2016-T2-2-043, RG3/15, RG114/15, RG114/18)。
代表性论文(#共同一作,*通讯)
1.Wang, C.-S.#;Sun, Q.#;Wang,G.-W.;He, W.; Fang, Z.; Guo, K. Recent Advances in Organic Reactions Using Water as Solvent. (Chapter — Green Solvents in Organic Synthesis. Edited by Wu, X. et al, Wiley2024)
2.Wang, C.-S; Xu, Y.; Wang, S.-P.; Zheng, C.-L.; Wang, G.-W.;Sun, Q*. Recent advances in selective mono-/dichalcogenation and exclusive dichalcogenation of C(sp2)–H and C(sp3)–H bonds.Org. Biomol. Chem.2024, DOI:10.1039/D3OB01847D (IF = 3.2,中科院2区).
3.Wang, C.-S; Xu, Y.; Zhou, Y.-L.; Zheng, C.-L.; Wang, G.-W.;Sun, Q*. Recent advances in the dichalcogenation reactions of unsaturated compounds via double functionlization.Org. Chem. Front.2023,10, 4972–5027. (IF = 5.4,中科院1区)
4.Sun, Q.; J.-F. Soulé*. Broadening of horizons in the synthesis of CD3-labeled molecules.Chem. Soc. Rev.2021,50, 10806-10835. (IF = 46.2,中科院1区top)
5.Wang, C.-S.#;Sun, Q.#; García, F.; Wang, C.; Yoshikai, N*. Robust cobalt catalyst for nitrile/alkyne [2+2+2] cycloaddition: Synthesis of polyarylpyridines and their mechanochemical cyclodehydrogenation to nitrogen-containing polyaromatics.Angew.Chem. Int. Ed.2021.60, 9627-9634. (IF = 16.6,中科院1区top)
6.Sun, Q.;Yoshikai, N*. Cobalt-catalyzed tandem radical cyclization/C–C coupling initiated by directed C–H activation.Org. Lett.2019,21, 5238-5242. (IF = 5.2,中科院1区)
7.Sun, Q.;Yoshikai, N*. Cobalt-catalyzed C(sp2)–H/C(sp3)–H coupling via directed C–H activation and 1,5-hydrogen atom transfer.Org. Chem. Front.2018,5, 582-585. (IF = 5.4,中科院1区)
8.Sun, Q.;Yoshikai, N*. Cobalt-catalyzed directedortho-methylation of arenes with methyl tosylate.Org. Chem. Front.2018,5, 2214-2218. (IF = 5.4,中科院1区)
9.Sun, Q.;Yao, Y.; Liu, C.; Li, H.; Yao, H.; Xue, X.; Liu, J.; Tu, Z.; Jiang, S*. Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry.Bioorg. Med. Chem. Lett.2013,23, 3295-3299. (IF = 2.7,中科院4区)
10.Lv, D.;Sun, Q.;Zhou, H.; Ge, L.; Qu, Y.; Li, T.; Ma, X.; Li, Y.; Bao, H. Iron-Catalyzed Radical Asymmetric Aminoazidation and Diazidation of Styrenes.Angew. Chem. Int. Ed.2021,60, 12455. (IF = 16.6,中科院1区)
11.Yang, J*.;Sun, Q.;Yoshikai, N*. Cobalt-catalyzed regio- and diastereoselective formal [3+2] cycloaddition between cyclopropanols and allenes.ACS Catal.2019, 9, 1973. (IF = 12.9,中科院1区)
12.Yao, Y.; Liao, C.; Li, Z.; Wang, Z.;Sun, Q.;Liu, C.; Yang, Y.; Tu, Z.; Jiang, S*. Design, synthesis, and biological evaluation of 1,3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.Eur. J. Med. Chem.2014,86, 639. (IF = 6.7,中科院1区)
13.Li, X.; Tu, Z.; Li, H.; Liu, C.; Li, Z.;Sun, Q.;Yao, Y.; Liu, Ji.; Jiang, S*. Biological evaluation of new largazole analogues: Alteration of macrocyclic scaffold with click chemistry.ACS Med. Chem. Lett.2013,4, 132. (IF = 4.2,中科院3区)
发明专利
1.姚炼滨,孙巧,王晓炜,朱景仰,一种芳基腈类化合物的制备方法,CN116332794A
2.蒋晟,涂正超,孙巧,刘春平,姚毅武,邱亚涛,含氮杂环衍生物,其制备方法及其在制备组蛋白去乙酰化酶Ⅰ抑制剂中的应用,CN103086971A
3.蒋晟,涂正超,白进红,邱亚涛,孙巧,李西才,周学让,杂环羟肟酸类化合物及其药用组合物和应用,CN103664734A