报告时间：2017年6月22日周四14:00
报告地点：科技创新大楼C501室
报告题目：Transforming Conventional Materials via Rational Design and Controlled Synthesis

Transforming Conventional Materials via Rational Design and Controlled Synthesis
Jianjun Cheng

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61821, USA

Abstract:

I will cover three separate topics in my presentation to highlight research conducted in my group in the past five years. I will first present the development of charged, helical polypeptides and their applications in gene delivery, bacterial inhibition and cell membrane penetration. We successfully transformed the conventional polypeptides to highly useful materials with exceptional biological membrane activities that can undergo direct membrane pore formation in energy-independent manner. I will also present rational design of helix-to-coil and coil-to-helix transitions of polypeptides and their applications in unpackaging DNA, lowering intracellular toxicity and inhibiting bacterial at extreme pH. For the second topic, I will discuss the transformation of conventional silica nanoparticles to advanced nanomedicines. Specifically, I will present the design and synthesis of size precisely controlled silica nanoconjugates and their applications as drug delivery nanomedicine, and discuss the use of these size controlled silica nanoconjugates in various fundamental studies, such as cellular uptake, biodistribution, tumor tissue penetration and inhibition. I will then cover the third topic in the last part of my presentation and discuss our recent efforts on transforming conventional urea-based polymeric materials to functional polymers. Specifically, I will present the design of hindered urea bonds and the dynamic chemistry associated with these bonds. Using the reversible, dynamic hindered urea bonds, we successfully developed polymers capable of catalyst-free dynamic property change and autonomous repairing at low temperature. I will also briefly discuss the use of polymers containing hindered urea bonds as biomaterials for controlled release and drug delivery applications.

Biosketch:

程建军1993年获天津南开大学化学学士学位，1996年获美国南伊利诺伊大学化学硕士学位，2001年获加州大学圣巴巴拉分校（University of California, Santa Barbara）材料科学博士学位。毕业后作为资深科学家在Insert Therapeutics工作三年至2004年，后又在麻省理工学院从事博士后研究至2005年，同年就职伊利诺伊大学厄巴纳 - 香槟分校（University of Illinois at Urbana-Champaign）材料科学与工程系任助理教授，2011年晋升为终身副教授，2015年晋升为该系终身正教授并获得伊利诺伊大学杰出晋升教授奖，2016年晋升为Hans Thurnauer 讲席教授。2015年起任苏州大学功能纳米与软物质研究院讲座教授。程建军教授课题组共发表过文章160余篇, 拥有/已申请37项美国或国际专利。获得的荣誉包括美国国家自然科学基金会青年学者奖和美国国立卫生研究院院长创新奖，以及五次伊利诺伊大学优秀教学奖。他是美国医学与生物工程学院会士(American Institute for Medical and Biological Engineering Fellow (AIMBE Fellow))，美国化学会高分子化学会士（ACS-POLY Fellow），美国科学促进会会士 （American Association for the Advancement of Science Fellow）， 以及英国皇家化学会Biomaterials Science会刊的创刊副主编。研究领域包括高分子化学，多肽，纳米材料和纳米药物、药物输送、癌症靶向技术。