报告题目：Mechanical Engineering of Protein-based Biomaterials: from singlemolecule featuresto macroscopic traits
报告人：李宏斌 教授
邀请人：霍峰蔚 教授
报告时间：10月10日（周三）14:30
报告地点：科技创新大楼C501室
Abstract
Elastomeric proteins function as molecular springs in their biological settings to establish elastic connections, and provide mechanical strength, elasticity and extensibility. To fulfill their biological functions, elastomeric proteins have evolved to assume different structures, from simple random coil-like structure to more sophisticated beads-on-a-string conformation, and
exhibit distinct mechanical properties. The development of single molecule force spectroscopy techniques has made it possible to directly probe the mechanical properties of such elastomeric proteins at the single molecule level and allowed to understand molecular design principles of these complex protein polymers. This knowledge has enabled us to engineer novel elastomeric proteins to achieve tailored and well-defined nanomechanical properties. Going a step further, we have started to employ these novel elastomeric proteins as building blocks to construct protein-based biomaterials, which in turn provide an ideal system to understand how single molecule nanomechanical features are translated into biomechanical properties of macroscopic materials. These studies will pave the way to utilizing proteins as building blocks to engineer new generations of protein-based
biomaterials for diverse applications in biomedical engineering as well as material sciences.
Reference
1. Lv, S., Dudek, D.M., Cao, Y., Balamurali, M.M., Gosline, J. & Li, H. Nature, 465, 69-73 (2010)
2. Li, H. and Cao, Y., Acc. Chem. Res. 43, 1331-1341 (2010).
3. Fang, J., Mehlich, A., Koga, N., Huang, J., Koga, R., Gao, X., Hu, C., Jin, C., Rief, M., Kast, J.,Baker, D., Li, H. Nature Commun., 4, 2974 (2013).
4. Kong, N., Peng, Q. and Li, H., Adv. Funct. Mater. 24, 7310–7317 (2014).
5. Gao, X., Fang, J., Xue, B., Fu, L. and Li, H. Biomacromolecules, 17, 2812?2819 (2016).
Biography
Education
09/1993-12/1998 Ph. D., Polymer Chemistry and Physics, Jilin University, P. R. China
09/1996 –09/1997 Joint training Ph.D. student, University of Munich, Germany
09/1989-07/1993 B. S., Polymer Engineering; Minor: Technical Economy and Management, TianjinUniversity, P. R. China
Professional Experience
07/2013-present Professor, Department of Chemistry, University of British Columbia, Canada
10/2004-09/2014 Canada Research Chair (Tier II) in Molecular Nanoscience and Protein Engineering,Department of Chemistry, University of British Columbia, Canada
07/2009-06/2013 Associate Professor with tenure, Department of Chemistry, University of BritishColumbia, Canada
08/2004-06/2009 Assistant Professor, Department of Chemistry, University of British Columbia,Canada
08/2002-08/2004 Associate Research Scientist, Columbia University, New York, NY, USA.
01/1999-08/2002 Research Fellow, Mayo Medical Center, Rochester, MN, USA
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