硕士生导师

联系方式：Email: iamjhliu@njtech.edu.cn

教育工作经历

2007年毕业于黑龙江大学，同年进入湖南大学攻读硕士和博士学位，之后在香港大学开展博士后工作，2015年12月加入万博体育bet 先进材料研究院。

学术成绩

主要聚焦于光电生物传感方面的研究。近年来，以第一/通讯或合作者身份在Nat.Commun.、Adv. Mater.、ACSNano、Anal. Chem.、Biosens. Bioelectron.、ACS Appl. Mater. Inter.、Sensor Actuat B-Chem.、Chem. Commun.和Talanta等SCI期刊发表论文50多篇，同行引用2000余次；主持国家自然科学基金三项、省级项目/开放课题/横向课题项目多项。担任Adv. Mater., Anal. Chem., Biosens. Bioelectron., ACS Appl. Mater. Inter., Sensor Actuat B-Chem., Talanta,Cellulose等期刊的审稿人。

研究方向

聚焦于光电生物传感研究，主要围绕多功能纳米材料展开（1）荧光酶联免疫试剂盒的研发；（2）智能健康柔性电子生物芯片的研发;发展面上国家大健康的早期疾病诊断新技术和新方法。

代表性论文：

1.H. Yang, S. Zhu, L. Pang, Y. Ma, X. Liu,J. Liu*, Cu²⁺-triggered wavelength-tunable real-time in situ fluorogenic immunoassay for detection of cTnI in human serum,Sensors&Actuators: B. Chemical,2024,406,135388.

2.Q. Ci, H. Yang, Y. Bian, Z. Li,J. Liu*, J. Wei, N.Yang, J. Chen, L. Li *, C.Zhang*, Anin situfluorescent copolymer dots-based kit for the specific detection of monoamine oxidase-A in cell/tissue/human prostate cancer,Sensors&Actuators: B. Chemical,2023,397,134655.

3.L.Zhang#, Q. Wu#, M. Ren, H. Zhang, X. Zhang,J. Liu*, and Z. Fu*, N-Heterocyclic Carbene-Catalyzed Atroposelective Synthesis of 5-Indo-1-yl Pyran-2-ones with an N-C axis from Enals,Adv. Synth. Catal.2023,365, 1-7.

4.W.Ma, L. Pang,J. Liu*, L. Wen, H. Ma, Y.Li*, Z. Xu, C. Zhang, and H. Yu*, MnO₄⁻‑triggered immediate-stable real-time fluorescence immunosensor with high response speed and low steady-state error,Analytical Chemistry.2023,95, 6323-6331.

5.Y. Sun#, L.Wen#, H.Ma#, W. Ma, Z. Fu, Yinhui Li*, C. Zhang, L. Li,J. Liu*,Engineering trienzyme cascade-triggered fluorescent immunosensor platform by sequentially integrating alkaline phosphatase, tyrosinase and horseradish peroxidase,Chinese Chemical Letters,2023, 34, 107654.

6.F. Geng #, X. Liu #, T. Wei, Z. Wang,J. Liu*, C. Shao, G. Liu, M. Xu *, L. Feng*, An alkaline phosphatase-induced immunosensor for SARS-CoV-2 N protein and cardiac troponin I based on the in situ fluorogenic self-assembly between N-heterocyclic boronic acids and alizarin red S,Sensors&Actuators: B. Chemical,2023,378,133121.

7.Z. Hu, # C. Wei, # Q. Shi, # X. Hong, #J. Liu,#(共一) X. Zhou, J. Han, W. Cao, A. Gupta, X. Zhang, D.Wei*, Z. Fu*, W.Huang, Desymmetrization of N-Cbz Glutarimides through N-Heterocyclic Carbene Organocatalysis,Nature Communications,2022,13, 4042.

8.J. Liu*, G. Ruan, W. Ma, Y. Sun, H. Yu, Z.Xu, C.Yu, H. Li, C. Zhang,* and L. Li,* Horseradish peroxidase-triggered directin situfluorescent immunoassay platform for sensing cardiac troponin I and SARS-CoV-2 nucleocapsid protein in serum.Biosensors and Bioelectronics.2022,198,113823.

9.L. Ke, #J. Liu, # (共一) Y.Hu, X. Zhang, X.Zhang, Y. Wang, Y. Luo, W. Wang, Y.Yan,* H. Lin, K. Rui, J. Zhu,* and Y. Zhu*, Compressive space dynamics manipulation enabling wearable fiber sensors for highly sensitive human micromotion monitoring,Adv. Mater. Technol.,2022, 2101544

10.X. Hong, #J. Guo, #J. Liu, #(共一)W. Cao, C. Wei, Y. Zhang, X. Zhang, Z. Fu*. Organocatalytic Dynamic Kinetic Resolution of N-Arylindole Lactams: Atroposelective Construction of Axially Chiral Amino Acids Bearing a C-N Chiral Axis,SCIENCE CHINA Chemistry,2022,65,905-911.

11.C. Chen, G. Ruan, Y. Sun, L. Wang,* C. Zhang,J. Liu,* In situ Cu²⁺-triggered wavelength-tunable fluorescent sensor for highly sensitive sensing inorganic pyrophosphatase activity and its logic gate application,Sensors&Actuators: B. Chemical,2021,346,130439.

12.Q. Ci, X. Qin,J. Liu*,R. Wang, Z. Li, W. Qin, K. Lim, C. Zhang* and L. Li*, Mitochondria-targeted polydopamine nanoprobes for visualizing endogenous sulfur dioxide derivatives in a rat epilepsy model,Chem.Comm.,2020, 56, 11823-11826.

13.J. Liu*,C.Zou, C.Chen, H. Fang, Q. Wu, H. Yu, J. Zhu*, L. Li*, S. Yang, W. Huang, Topochemical assembly of levodopa nanoparticles network as a high performance biosensing platform coupling with π-π stacking and electrostatic repulsion interactions,Talanta,2020,219, 121285.

14.C. Chen, C. Zou, L. Li, H. Yu, J. Zhu,J. Liu*, Wei Huang, Blue and green emission-transformed fluorescent copolymer: Specific detection of levodopa of anti-Parkinson drug in human serum,Talanta,2020,214, 120817.

15.Y. Jiao, C. Du, L. Zong, X. Guo, Y. Han, X. Zhang, L. Li, C. Zhang, Q. Ju,J. Liu*, H. Yu*, W.Huang*, 3D vertical-flow paper-based device for simultaneous detection of multiple cancer biomarkers by fluorescent immunoassay,Sensors & Actuators: B. Chemical,2020,306,127239.

16.F. Geng, C. Zou,J. Liu,* X. Guo, Y. Fan,* H.Yu, S. Yang, Z. Liu,* L. Li, Development of luminescent nanoswitch for sensing of alkaline phosphatase in human serum based on Al³⁺-PPi interaction and Cu NCs with AIE properties,Anal. Chim. Acta.,2019,1076, 131-137.

17.C. Chen, F. Geng, Y. Wang,* H. Yu, L. Li, S. Yang,J. Liu,* W.Huang, Design of a nanoswitch for sequentially multi-species assay based on competitive interaction between DNA-templated fluorescent copper nanoparticles, Cr³⁺and pyrophosphate and ALP,Talanta,2019, 205, 120132.

18.X. Guo, L.Zong,Y. Jiao,Y. Han, X. Zhang, J. Xu, L. Li, C. Zhang, Z. Liu, Q. Ju,J. Liu,* Z. Xu,* H. Yu,* W. Huang*, Signal-Enhanced Detection of Multiplexed Cardiac Biomarkers by a Paper-Based Fluorogenic Immunodevice Integrated with Zinc Oxide Nanowires,Anal. Chem.2019, 91, 9300-9307.

19.L. Gao, C.Zhu, L. Li, C. Zhang,J. Liu,* H. Yu,* W. Huang*, All paper-based flexible and wearable piezoresistive pressure sensor,ACS Appl. Mater. Interfaces,2019, 11, 25034-25042.

20.Q. Ci,J. Liu, * X. Qin, L. Han, H. Li, H. Yu, K. Lim, C. Zhang, * L. Li,* W. Huang, Polydopamine dots-based fluorescent nanoswitch assay for reversible recognition of glutamic acid and Al³⁺in human serum and living cell,ACS Appl. Mater. Interfaces,2018,10, 35760-35769.

21.S. Zhang, #C. Chen, # X. Qin, Q. Zhang,J. Liu,* J. Zhu, Y. Gao, L. Li, W. Huang, Ultrasensitive detection of trypsin activity and inhibitor screening based on the electron transfer between phosphorescence copper nanocluster and cytochrome c,Talanta,2018,189, 92-99.

22.Q. Zhang, D. Zhao, C. Zhang,J. Liu,* Z. An, X. Qin, Y. Gao,* S. Zhang, L. Li,* W. Huang. An effective signal amplifying strategy for copper (II) sensing by using in situ fluorescent proteins as energy donor of FRET.Sensor Actuat B: Chem.,2018,259, 633-641.

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