Nickel-Catalyzed Direct Cross-Coupling of Unactivated ArylFluorides with Aryl Bromides

Jing-Ao Ren,^aJin-He Na,^aChao Gui,^aChengping Miao,^bXue-Qiang Chu,^aMengtao Ma,^cHao Xu,*^aXiaocong Zhou,*^band Zhi-Liang Shen*^a

^aTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China. E-mail:xuhao@njtech.edu.cn;ias_zlshen@njtech.edu.cn.

^bCollege of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, China. E-mail: xczhou@zjxu.edu.cn.

^cCollege of Science, Nanjing Forestry University, Nanjing 210037, China.

Abstract:A nickel-catalyzed direct cross-coupling of unactivated aryl fluoride with aryl bromide is realized. The “one-pot” reaction, which avoids the use of preformed and sensitive organometallic reagents, proceeded effectively via C-F bond cleavage at room temperature in THF in the presence of phosphine ligand and magnesium powder (with or without TMSCl) to produce the desired biaryls in modest to good yields.

Organic Letters2023,25, 5525-5529.(highlighted byOrg. Process Res. Dev. 2023, 27, 1827−1840.Impact factor: 5.2)

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.3c02000