“On-Water” Synthesis of Sterically Congestedγ-KetophosphineOxides Featuring a CF₃- and P(O)-Tetrasubstituted CarbonCenter

Man-Hang Feng,^aWen-Jun Ji,^aBo-Jie Huo,^aHao Xu,^a*Mengtao Ma,^bZhi-Liang Shen,^a*and Xue-Qiang Chu^a*

^aTechnical Institute of Fluorochemistry, Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People’s Republic of China.E-mail: xuhao@njtech.edu.cn; ias_zlshen@njtech.edu.cn; xueqiangchu@njtech.edu.cn.

^bDepartment of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing 210037, People’s Republic of China.

Abstract:The distinctive hydrophobic hydration effect in the aqueous solution contributes to thesuccess of the phospha-Michael reaction betweenβ-CF₃-β,β-disubstituted enones and diarylphosphine oxides, providing an access to biologically relevantγ-ketophosphine oxides bearing a sterically highly congested CF₃- and P(O)-tetrasubstituted carbon center. More importantly, the resulting products could be further transformed into densely functionalizedγ-ketophosphine oxides containing a CF₃- and P(O)-tetrasubstituted carbon center.

Advanced Synthesis & Catalysis2023,365, 3546-3552. (Impact factor: 5.4)

论文链接：https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.202300741