Reductive-Delay Heck 1,1-Diarylation of Terminal Alkenes

Huihui Shao,^†Yao Zhao,^†Shuangqiang Wang,^‡Rizhi Chen,^‡Jianrong Steve Zhou,^§and Xiaojin Wu^†*

^†Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China

^‡State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China

^§State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory ofChemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School, Shenzhen 518055,China

Abstract: Pd-catalyzed chemo- and regiocontrollable 1,1-diarylation of unactivated aliphatic alkenes with two aryl halides was developed. Under the cationic reductive-delay Heck pathway, the first aryl insertion is followed by β-H elimination, while the second aryl insertion is terminated by C−H bond formation.

Org. Lett.2022.DOI:10.1021/acs.orglett.2c02416. (Impact factor: 6.072)

论文链接:https://doi.org/10.1021/acs.orglett.2c02416