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褚雪强、沈志良团队在《The Journal of Organic Chemistry》发表研究论文
阅读次数:添加时间:2022/09/01 发布:

Nickel-Catalyzed Direct Cross-Coupling of Diaryl Sulfoxide with Aryl Bromide

W.-X. Li,aB.-W. Yang,aX. Ying,aZ.-W. Zhang,aX.-Q. Chu,*aX. Zhou,*bM. Ma,cZ.-L. Shen*a


aTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

bCollege of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, China.

cJiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China


Abstract:The direct cross-couplings of diaryl sulfoxides with aryl bromides via C−S bond cleavage could be readily accomplished using nickel(II) as the catalyst, 1,2-bis(diphenylphosphino)ethane (dppe) as the ligand, and magnesium turnings as the reducing metal in THF, leading to the corresponding biaryls in moderate to good yields. The reaction exhibited a broad substrate scope and could be applied to a gram-scale synthesis. The “one-pot” reaction, which avoids the utility of presynthesized and moisture-labile organometallic compounds, is operationally simple and step-economic.


J. Org. Chem.2022,DOI:10.1021/acs.joc.2c01513.(Impact factor:4.198)

论文链接:https://pubs.acs.org/doi/10.1021/acs.joc.2c01513


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