DMSO-Promoted Difluoroalkylation of Organophosphonium Salts with Difluoroenol Silyl Ethers

Z.-L. Yu,^#aJ.-W. Chen,^#aY.-L. Chen,^aR.-J. Zheng,^aM. Ma,^bJ.-P. Chen,*^aZ.-L. Shen,*^aX.-Q. Chu*^a

^aTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^bDepartment of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing, Jiangsu 210037, China.

Abstract:An efficient method for the synthesis of β,β-di(hetero)aryl-α,α-difluorinated ketones using readily available organophosphonium salts and difluoroenol silyl ethers has been developed. This mild reaction features a good functional group tolerance, a scaled-up synthesis, and synthetic simplicity. By taking advantage of DMSO as a less-toxic promoter and solvent for the difluoroalkylation and C−P bond functionalization, the use of transition-metal catalysts and sensitive additives could be avoided.

Org. Lett.2022,24,5557–5561,DOI:10.1021/acs.orglett.2c02088.(Impact factor: 6.072,^#Equal contribution, highlighted by CBG)

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.2c02088