1,n-Thiosulfonylation Using Thiosulfonates as Dual Functional Reagents

D. Ge,^aJ.-W. Chen,^aPei Xu,*^bJinyin Pan,^cX.-Q. Chu*^a

^aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^bJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.

^cSartorius Stedim (Shanghai) Trading Co., Ltd., Shanghai 200000, China.

Abstract:In recent years, the direct introduction of sulfonyl and sulfenyl groups into unsaturated substrates by using thiosulfonates as unique dual functional reagents has inarguably provided chemists a new platform for the diverse synthesis of important S-containing derivatives. These 1,n-thiosulfonylation reactions usually feature simple procedures, 100% atom economy, and high regioselectivity. This review focuses on the recent advancements in the transformations of thiosulfonates through 1,n-thiosulfonylation involving the formation of two distinct C-S bonds under transition-metal-catalyzed or metal-free conditions, where thiosulfonates act as both a sulfonyl and a sulfenyl component.

Chin. Chem. Lett.2022, 33,4732–4739, DOI:10.1016/j.cclet.2022.02.019. (Impact factor:8.455,Review)

论文链接：https://doi.org/10.1016/j.cclet.2022.02.019