Nickel/Photoredox-Catalyzed Enantioselective Reductive Cross-Coupling between Vinyl Bromides and Benzyl Chlorides

Qianqian Lu, Haixing Guan, Yan-En Wang, Dan Xiong, Tingzhi Lin , Fei Xue , Jianyou Mao

aTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, Schoolof Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu

Road, Nanjing 211816, P.R. China

Abstract:A visible-light-promoted nickel/photoredox-catalyzed reductive cross-coupling reaction between vinyl bromides and benzyl chlorides is reported. A diverse array of enantioenriched allylic centers containing products could be achieved in good yields (up to 90%) and high enantioselectivities (up to 95% ee). The mechanistic studies show that this reductive cross-coupling involves a radical pathway.

J. Org. Chem. 2022, 87, 12, 8048–805(2022年影响因子4.198)

论文链接：https://pubs.acs.org/doi/full/10.1021/acs.joc.2c00707