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美国莱斯大学László Kürti教授学术报告会
阅读次数:添加时间:2016/12/13 发布:管理员

Novel Direct Arylation and Amination Reactions:

Rapid Synthesis of Functionalized Biaryls,

α-Arylated Ketones, Arylamines and Heterocycles

人:LáSZLó KüRTI,Ph.D.

报告时间:2016年12月14日(星期三)下午13:30

报告地点:万博体育bet生物与制药工程学院多功能会议厅

报告摘要:The growth of knowledge in the chemical sciences has seen a dramatic increase since the beginning of the 21st century. The advance is particularly significant in synthetic chemistry because of its centrality and value to society. Key to all of this is the constant development of novel C-C and C-heteroatom bond-forming strategies, methods and reagents that expand the toolbox of synthetic organic chemists and enable the environmentally friendly construction of complex molecular structures using the fewest number of chemical steps and generating the least amount waste. The Kürti lab has been exploring several fundamentally new strategies for the transition-metal-free direct: (i) arylation of arenes; (ii);α-arylation of ketones, esters and amides; (iii) O-arylation of oximes; (iv) primary amination of arylboronic acids and (v) intramolecular C(sp2)-H amination of arenes. We have also discovered, in collaboration with the Falck (UTSW) and Ess labs (BYU), the Rh-catalyzed direct N-H/N-alkyl aziridination of olefins, a transformation that eluded synthetic chemists for decades. These methods have one common feature: a weak N-N or N-O bond is cleaved in order to form a stronger C-C or C-N bond. In-depth experimental and computational studies have already identified the critical factors required for efficient alkyl-aryl, aryl-aryl, O-aryl and N-aryl bond-formation and led to several innovative and environmentally benign methods for the rapid preparation of structurally diverse arylated carbonyl compounds, functionalized biaryls as well as O- and N-heterocycles.

个人简历:

2015.06至今

美国莱斯大学,终身副教授

2010-2015

美国德克萨斯大学西南医学中心,助理教授

2006-2010

美国哈佛大学,博士后

2001-2006

美国宾夕法尼亚大学,有机化学博士

2001.06

哥伦比亚密苏里大学,有机化学硕士

1998.06

匈牙利德布勒森大学,化学专业

1997.06

匈牙利德布勒森大学,匈牙利语-英语翻译专业

获奖荣誉:

vBiotage 青年首席研究员奖

2015.11

vNSF事业奖

2015-2020

v日本学术振兴会研究学者奖

2014.08

vAmgen 青年研究员奖

2014.04

vThieme化学期刊奖

2010.11

vUTSWMC生物医学研究创业资金

2010.09

vDamon Runyon癌症奖学金

2007.06

v共和国奖学金(匈牙利政府)

1997-1998


地址:南京浦口区浦珠南路30号 邮编:211880 电话:025-58139535、9536、9537 邮箱:chem@njtech.edu.cn

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