Designed Chemical Synthesis and Assembly of Uniform-sized Nanoparticles for Medical Applications

报告人：Taeghwan Hyeon

（J. Am. Chem. Soc.副主编、首尔国立大学特聘教授）

报告时间：2017年10月27日（星期五）下午16:00

报告地点：万博体育bet 江浦校区浦江楼302会议室

报告摘要：

Over the last 18 years, our laboratory has focused on the designed chemical synthesis, assembly and applications of uniform-sized nanocrystals. In particular, we developed a novel generalized procedure called as the “heat-up process” for the direct synthesis of uniform-sized nanocrystals of many metals, oxides, and chalcogenides.

For the last 10 years, our group has been focused on medical applications of various uniform-sized nanoparticles. Using 3 nm-sized iron oxide nanoparticles, new non-toxic MRI contrast agent was realized for high resolution MRI of blood vessels down to 0.2 mm. Very recently, we report on the biocompatibility evaluation and MR imaging of extremely small and uniform-sized iron oxide nanoparticles in large animal models including most clinically-relevant non-human primates. These biocompatible iron oxide nanoparticles are successfully used as T1 MR contrast agent for high-resolution MR angiography of macaque monkeys.

We demonstrated that intravenously administered ceria nanoparticles could substantially reduce the damage from ischemic strokes, and that triphenylphosphonium-conjugated ceria nanoparticles can localize to mitochondria and suppress neuronal death in 5XFAD transgenic Alzheimer’s disease mouse model. We reported that 2 nm-sized ceria–zirconia nanoparticles (Ce0.7Zr0.3O2 (7CZ) NPs) can greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models.

I will present recent advances on the fabrication of ultraflexible and stretchable electronic and optoelectronic devices integrated with various functional nanomaterials and their applications to wearable and implantable healthcare devices. We reported graphene-hybrid electrochemical devices integrated with thermo-responsive micro-needles for the sweat-based diabetes monitoring and feedback therapy. We reported the designed fabrication of multifunctional wearable electronic devices for sensing, data storage, and drug-based feedback therapy of motion-related neurological disorders such as Parkinson’s disease. We introduced electromechanical cardioplasty using an epicardial mesh made of electrically conductive and mechanically elastic silver nanowire-rubber composite material to resemble the innate cardiac tissue and confer cardiac conduction system function.

个人简介：

1996年，于美国伊利诺伊大学香槟分校获博士学位；之后在美国西北大学催化中心从事博士后研究工作；1997年回国，加入首尔国立大学化学与生物工程学院，先后被评为助理教授、副教授和教授。2010年起，开始担任J. Am. Chem. Soc.副主编；2012年8月至今，在韩国基础科学研究所担任纳米粒子研究中心主任；2017年3月成为首尔国立大学特聘教授。

研究领域：

1.Synthesis and characterization of Nanomaterials

2.Medical Applications of Nanomaterials

3.Energy and Catalytic Applications of Nanomaterials