Transition-Metal-Free Regioselective and Stereoselective C(sp²)-C(sp³) Coupling of Enamides with Ethers or Alkanes via Photore-dox-Catalyzed Cross-Dehydrogenative Coupling Reactions

Ji-Yu Tao,^†aYing-Xue Wang,^†aQing-Hong Zhang,^†aKun-Ni,^†aTong-Hao Zhu^†dand Kai Zhao^{*a, b, c}

^aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China.

^bKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

^cGuangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China.

^dInstitute of Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China.

^†These authors contributed equally.

Abstract:A generally applicable and robust regio- and stereoselective cross-dehydrogenative-coupling of enamides with ethers or alkanes via transition-metal-free photoredox-catalysis under environmentally benign and atom economic conditions is demonstrated. The visible-light-induced transformations proceed smoothly with the aid of non-expensive and non-poisonous organic dyes, forging geometrically-defined and synthetically paramount β-alkylated enamides with broad substituent diversity and functional group compatibility.

Green Chem.,2022,24,4004-4011. (2021年影响因子: 10.182).

论文链接：https://doi.org/10.1039/D2GC00472K