Nickel-catalyzed direct cross-coupling of aryl sulfonium salt with aryl bromide

Na-Na Ma,^†Jing-Ao Ren,^†Xiang Liu,^†Xue-Qiang Chu,^†Weidong Rao,^‡and Zhi-Liang Shen*^,†

^†Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China. E-mail: ias_zlshen@njtech.edu.cn.

^‡Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.

Abstract:The direct cross-couplings of aryl sulfonium salts with aryl halides could be achieved by using nickel as reaction catalyst. The reactions proceeded efficiently via C-S bond activation in the presence of magnesium turnings and lithium chloride in THF at ambient temperature to afford the corresponding biaryls in moderate to good yields, potentially serving as an attractive alternative to conventional cross-coupling reactions employing pre-prepared organometallic reagents.

Org. Lett.2022,doi:10.1021/acs.orglett.2c00357.(Impact factor:6.005)

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.2c00357