Dehydrative Allylation of Alkenyl sp2 C-H Bonds

Xinying Cai^†, Huicong Xing^†, Ju Qiu^†, Bowen Li^†, and Peizhong Xie^†*

†School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.

Abstract:Wedesigneda cooperative catalytic system by combining commercially available Ca(NTf₂)PF₆and Pd(PPh₃)₄to address the dehydrative allylation of alkenylsp²C-Hbondsin an environmentally benign manner. A novel C-OH bond cleavagemethodwas found to be crucial for this practical protocol. A variety of alkenes and allylic alcohols equipped with wide-spectrum functional groups can be successfully incorporated into the desired cross-coupling, affording 1,4-dienes withmoderateto excellentyieldsand high stereo- andregioselectivity.

Org. Lett.2021,23,4368-4373.（影响因子：6.005）

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.1c01309