Visible-Light-Induced Trifluoromethylation of Allylic Alcohols

Bowen Li^†, Wubing Zeng^†,LinWang^†,Zhishuai Geng^‡, Teck-Peng Loh*^§_,and Peizhong Xie*^†

^†School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.

^‡School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.

^§Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.

Abstract:Anorganic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developedin anenvironmentally benignmanner. In this reaction, the readily available CF₃SO₂Na was selected as the trifluoromethylative reagent. Thein situgenerated byproduct SO₂was reutilizedto activate C-OH bond, which enabled thisdehydroxylativetrifluoromethylationto beperformedconveniently. A variety of multi-functionalizedCF₃-allylic compounds were obtainedin highyields andexcellent stereoselectivity.

Org. Lett.2021,23, 5235-5240.（影响因子：6.005）

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.1c01767