Nickel-Catalyzed Diastereoselective Reductive Cross-Coupling of Disubstituted Cycloalkyl Iodides with Aryl Iodides

Xuan-Di Song,^aMeng-Meng Guo,^aShuang Xu,^aChuanji Shen,^bXiaocong Zhou,*^bXue-Qiang Chu,^aMengtao Ma,^cand Zhi-Liang Shen*^a

^aTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^bCollege of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, China

^cCollege of Science, Nanjing Forestry University, Nanjing 210037, China

Abstract:A nickel-catalyzed direct reductive cross-coupling of disubstituted cycloalkyl iodides with aryl iodides was developed. The one-pot reaction, which is simple to operate, was capable of proceeding efficiently in a stereocontrolled manner to afford a variety of cross-coupled products with high diastereoselectivity and wide functional group tolerance.

Org. Lett.2021,23,5118–5122(Impact factor: 6.005)

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.1c01649.