褚雪强
万博体育bet
Email: xueqiangchu@163.com; xueqiangchu@njtech.edu.cn
ORCID: 0000-0002-9173-1508; Researcher ID: T-3254-2018
主页：http://chem.njtech.edu.cn/info/1073/3152.htm
课题组网站：https://www.x-mol.com/groups/shen_zhiliang/people/32605
课题组每年招收硕士研究生3-6名欢迎报考!
教育、工作经历：
(5)2022.12-，麦吉尔大学，博士后（CSC）（合作导师：Chao-JunLi教授）
(4)2019.01-，万博体育bet ，化学与分子工程学院（IAS），讲师、副教授（合作者：沈志良教授）
(3) 2017.07-2018.12，万博体育bet ，先进化学制造研究院，助理教授（合作者：沈志良教授和Teck-Peng Loh教授）
(2) 2012.09-2017.06，苏州大学，博士（导师：纪顺俊教授和徐小平教授）
(1) 2008.09-2012.06，苏州大学，学士（导师：纪顺俊教授和徐小平教授）
研究方向：
多重C-F键官能化、含氟杂环化合物合成、绿色化学
研究小结：
在多重C-F键官能化反应研究方面，取得了具有重要影响力的原创性研究成果。先后在国内外有影响的学术刊物，如Chemical Reviews,Chem,ACS Catalysis,Green Chemistry, Organic Letters, iScience等上公开发表论文近百篇，其中以第一作者或通讯作者身份公开发表>50篇论文，包含ESI热点论文1篇，ESI高被引论文3篇，一篇入选2022 Green Chemistry Hot Articles论文，一篇论文曾被ACS Catalysis主编选为ACS Editors' Choice，H-index 19，多篇论文被Frontiers Journals、Organic Chemistry Portal、X-MOL，CBG，化学加等作为亮点进行报道和评述。参与撰写书章节1章，已申请或授权的专利十多项。目前为Journal of the American Chemical Society, Angewandte Chemie International Edition, Organic Letters, Chemical Communication, Chemistry - A European Journal, The Journal of Organic Chemistry等期刊特邀审稿人。
科研项目：
国家自然科学基金项目（22001121），24万，负责人，在研;
江苏省自然科学基金项目（BK20180690），20万，负责人，结题;
万博体育bet 科研启动经费（39837146），20万，负责人，在研;
国家自然科学基金项目（21772138），64万，骨干，结题;
所获荣誉：
教育部国家奖学金三次（2011 & 2015 & 2016）;
苏州大学各类奖学金（2010-2017）;
教育部《中国研究生》杂志123期封面人物;
“德国林岛诺贝尔获得者大会”评选活动，苏州大学代表（2017）;
苏州“四创”好青年候选人;
苏州大学优秀博士论文（2017）;
苏州大学优秀博士毕业生（2017）;
国家留学基金委资助（2019）;
万博体育bet 优秀本科论文指导教师（2020&2022）;
万博体育bet 化学与分子工程学院教育教学贡献奖（2021）;
万博体育bet 化学与分子工程学院科学研究贡献奖（2021）;
万博体育bet 化学与分子工程学院青年教师授课竞赛二等奖（2022）;
万博体育bet 微课竞赛二等奖（2022）;
教学信息：
主讲《有机化学
指导本科生（张要威、李琳、刘丽丽）获第十四届本科生学术科技论坛三等奖;
指导本科生（郭一聪）获得2020届校优秀本科毕业论文;
指导本科生（郭一聪）获得2020届江苏省优秀本科毕业论文三等奖;
指导研究生（谢婷）获得2020届校优秀硕士毕业论文;
指导本科生（罗鑫龙、唐茜）主持国家级大学生创新创业训练计划项目(202110291019Z)和校级项目多项;
协助指导研究生获国家奖学金（2019员金金、2020程步清、2021宋轩笛、2022张斯旋）;
指导研究生（孙莉雯）获2022年化学与分子工程学院“长青杯”研究生科技论坛暨校第二十指导四届研究生科技论坛分论坛一等奖;
指导研究生（孙莉雯）获2022万博体育bet 第二十四届科技论坛校二等奖;
指导本科生（王明铭）获得2022届校优秀本科毕业论文;
研究成果（仅列通讯或第一作者论文）：
54.X.-Q. Chu,*L.-W. Sun, J.-Wei Chen, Y.-L. Chen, M.-Q. Zhu, J. Zhou,* M. Ma, Z.-L. Shen,*“On-Water” Defluorophosphorylation of Trifluoromethylated Enones with Phosphine Oxides,2022,Submitted.
53.Z.-L. Yu,#J.-W. Chen,#Y.-L. Chen, R.-J. Zheng, M. Ma, J.-P. Chen,* Z.-L. Shen,*X.-Q. Chu,* DMSO-Promoted Difluoroalkylation of Organophosphonium Salts with Difluoroenol Silyl Ethers,Org. Lett.2022,24, 5557–5561. (IF 2022 = 6.072,#Equal contribution,highlighted by CBG)
52.Y.-L. Chen, L.-W. Sun, J.-W. Chen, M.-Q. Zhu, M. Ma, Z.-L. Shen,*X.-Q. Chu,* Four-Component Defluorinative Reaction of Allylic Fluorides, Amidines, and Cs2CO3under Transition-Metal-Free Conditions,Green Chem.2022,DOI:10.1039/D2GC02045A. (IF 2022 = 11.034)
51.W.-X. Li, B.-W. Yang, X. Ying,X.-Q. Chu,*X. Zhou,*M. Ma, Z.-L. Shen,*Nickel-Catalyzed Direct Cross-Coupling of Diaryl Sulfoxide with Aryl Bromide,J. Org. Chem.2022,DOI:10.1021/acs.joc.2c01513.
50.X.-Q. Chu,* S.-Z. Cai, Z.-L. Yu, J.-W. Chen, M. Ma,Patrick J. Walsh,* Z.-L. Shen,*Defluorophosphorylation of Fluoroalkyl Peroxides for the Synthesis of Organophosphorus Heteroarenes,2022,Submitted.
49.X.-Q. Chu,* Y.-L. Chen,#J.-W. Chen,#Z.-L. Yu, D. Ge, M. Ma,Z.Shi,* Z.-L. Shen,*Recent Advances inTransition-Metal-Catalyzed Enantioselective Defluorinative Reactions,2022,Submitted.(Review,#Equal contribution)
48. M.-M. Guo,#Z.-L. Yu,#Y.-L. Chen, D. Ge,* M. Ma, Z.-L. Shen,X.-Q. Chu,*Difluorinated Silyl Enol Ethers as Fluorine-Containing Building Blocks for the Synthesis of Organofluorine Compounds,Chin. J. Org. Chem.2022, DOI: 10.6023/cjoc202204060. (In Chinese, Review)
47. Q.-D. Wang,* S.-X. Zhang, Z.-W. Zhang, Y. Wang, M. Ma,X.-Q. Chu,* Z.-L. Shen,* Palladium-Catalyzed Sonogashira Coupling of Heterocyclic Phosphonium Salt with Terminal Alkyne,Org. Lett.2022,24, 4919–4924. (IF 2022 = 6.072)
46.X.-Q. Chu,* L.-W. Sun, Y.-L. Chen, J.-W. Chen, Z.-L. Shen,*HP(O)Ph2/H2O-Promoted Hydrodefluorination of Trifluoromethyl Alkenes,Green Chem.2022,24, 2777–2782. (IF 2022 = 11.034,2022 Green Chemistry Hot Articles,highlighted by CBG)
45. D. Ge, Zhenhua Jia,X.-Q.Chu,*TMSCF2Br as Both a C1 Synthon and a F1 Reagent,Green Synth. Cat.2022, DOI: 10.1016/j.gresc.2022.02.001.(Invited Highlight)
44. M.-M.Guo,#X.-D. Song,#X. Liu, Y.-W. Zheng,X.-Q. Chu,*W. Rao, Z.-L. Shen,*Iron(III)-Catalyzed Difluoroalkylation of Aryl Alkyne with Difluoroenol Silyl Ether in the Presence of Trimethylsilyl Chloride,Adv. Synth. Catal.2022, 364, 2454–2460. (IF 2022 = 5.981,#Equal contribution)
43. D. Ge, J.-W. Chen, Pei Xu,* Jinyin Pan,X.-Q. Chu,* 1,n-Thiosulfonylation Using Thiosulfonates as Dual Functional Reagents.Chin. Chem. Lett.2022, 33,4732–4739. (IF 2020 = 8.455,Review)
42. W.-X. Li, B.-W. Yang, J.-H. Na, W.-D. Rao,X.-Q. Chu,* Z.-L. Shen,* Palladium-Catalyzed Cross-Coupling of Alkylindium Reagent with Diaryliodonium Salt,Tetrahedron Lett.2022,95, 153729. (IF 2022 = 2.032)
41.D. Ge,X.-Q.Chu,* Multiple-Fold C-F Bond Functionalization for the Synthesis of (Hetero)cyclic Compounds: Fluorine as a Detachable Chemical Handle.Org. Chem. Front.2022,9, 2013–2055.(IF 2022 = 5.456,Review)
40. Y.-Y. Cui, J.-H. Na, M.-M. Guo, J.-Y. Huang,X.-Q. Chu,*W. Rao, Z.-L. Shen,*Cobalt-Catalyzed Cross-Coupling of Heterocyclic Phosphonium Salts with Arylmagnesium Reagents,Tetrahedron Lett.2022,92, 153662. (IF 2022 = 2.032)
39. L.-W. Sun, Z.-L. Yu, X.-L. Luo, M. Ma, Z.-L. Shen,*X.-Q. Chu,*Transition-Metal-FreeHydroamination/Defluorination/Cyclization of Perfluoroalkyl Alkynes with Amidines.Org. Chem. Front.2022,9, 109–116.(IF 2022 = 5.456,Featured inFrontiers Journals)
38. S.-X. Zhang,#X.-R. Li,#W.-X. Li, W.-D. Rao, D. Ge,* Z.-L. Shen,X.-Q. Chu,*Iron(0)-mediated Henry-type Reaction of Bromonitromethane with Aldehydes for the Efficient Synthesis of 2-Nitro-alkan-1-ols.Chin. J. Org. Chem.2022,42, 235-241.
37.X.-Q.Chu,* D. Ge, Y.-Y. Cui, Z.-L. Shen,* C.-J. Li.* DesulfonylationviaRadical Process: Recent Developments in Synthetic Applications.Chem. Rev.2021,121, 12548–12680. (IF 2021 = 60.622, Invited Review, ESI Hot Article, ESIHighlyCitedPaper,highlighted byX-MOL)
36. D. Ge, X. Wang,X.-Q. Chu,*SOMOphilic Alkynylation Using Acetylenic Sulfones as Functional Reagents.Org. Chem. Front.2021,8, 5145–5164.(IF 2021 = 5.281,Review)
35. Q.-D. Wang,* Y.-W. Wang, T. Xie, Y.-Y. Cui, M. Ma, Z.-L. Shen,X.-Q. Chu,* Three-Component Bisannulation for the Synthesis of Trifluoromethylated TetracyclicAza-Aromatics through Six C(sp3)-F Bond Cleavage and Four C-N Bond Formation.J. Org. Chem.2021,86, 8236–8247. (IF 2021 = 4.354)
34. S.-Z. Cai,#D. Ge,#L.-W. Sun, W. Rao, X. Wang, Z.-L. Shen,*X.-Q. Chu,* Three-Component Heteroannulation for Tetrasubstituted Furan Construction Enabled by Successive Defluorination and Dual Sulfonylation Relay.Green Chem.2021,23, 935–941. (IF 2021 = 10.182,ESIHighlyCitedPaper,#Equal Contribution)
33.X.-L. Luo,#D. Ge,#Z.-L. Yu,X.-Q. Chu,* P. Xu,* Vitamin B1-Catalyzed Aerobic Oxidative Esterification of Aromatic Aldehydes with Alcohols.RSC Adv.2021,11, 30937–30942. (IF 2021 =)
32. D. Ge,X.-Q. Chu,* Stepwise C(sp3)-F Bond Functionalizations of Trifluoroacetic Acid Derivatives.Chin. J. Org. Chem.2021,41, 2150–2151.(In Chinese,InvitedHighlight)
31.D. Ge, X. Wang,X.-Q. Chu,* Difluoroalkylation/1,2-Aryl Migration of Allylic Alcohols Under Transition Metal-Free Conditions.Tetrahedron Lett.2021,70, 153002.(IF 2021 = 2.415)
30. D. Ge, X.-L. Luo, X. Tang, C.-B. Pang, X. Wang,X.-Q. Chu,*Metal-Free [3 + 2 + 1] Annulation of Allylic Alcohols, Ketones, and Ammonium Acetate: Radical-Involving Synthesis of 2,3-Diarylpyridine Derivatives.Org. Biomol. Chem.2021,19, 2277–2283. (Featured in Org. Chem. Highlights: Heteroaromatics)
29. Q.-D. Wang,* C. Zhang, L.-W. Sun, X.-L. Luo, W. Rao, Z.-L. Shen,X.-Q. Chu,* Defluorinative Phosphorylation of Perfluoroalkyl Ketones: Synthesis of Fluoroalkylated and Phosphorylated Furan Derivatives.Org. Chem. Front.2021, 8, 1503–1509. (IF 2021 = 5.281,Featured inFrontiers Journals)
28. B.-Q. Cheng, D. Ge,*X. Wang,X.-Q. Chu,* Perfluoroalkyl Halides as Fluorine-Containing Building Blocks for the Synthesis of Fluoroalkylated Heterocycles.Chin. J. Org. Chem.2021,41, 1925–1938.(In Chinese, Review)
27.X.-Q. Chu,* M.-L. Zhi, S.-X. Zhang, Y.-W. Wang, W. Rao, H. Xu, Z.-L. Shen,* Palladium-Catalyzed Defluorinative Alkynylation of Polyfluoroalkyl Ketones with Alkynes for the Synthesis of Fluorinated Fused Furans.Org. Chem. Front.2021, 8, 572–578. (IF 2021 = 5.281)
26. D. Ge, M.-L. Wang, X. Wang,X.-Q. Chu,* Iron-Catalyzed C-O Bond Functionalization of Butyrolactam Derivatives with VariousN-/C-Nucleophiles.New J.Chem.2020,44, 21064–21069.
25.T. Xie,C. Zhang, S.-X. Zhang, W. Rao, H.-Y. Xu, Z.-L. Shen,*X.-Q. Chu,*Synthesis of Polycyclic Furan and Chromene DerivativesviaCascade Reactions Enabled by Cleavage of Multiple C(sp3)-F Bonds.Adv. Synth. Catal.2020,362, 4736–4743.
24.X.-Q. Chu,* T. Xie, Y.-W. Wang, X.-R. Li, W. Rao, H. Xu, Z.-L. Shen,*Synthesis of Di(hetero)aryl Sulfides by Defluorinative Sulfenylation of Polyfluoroalkyl Ketones with Sodium Sulfinates or Arylsulfonyl Chlorides.Chem. Commun.2020,56, 8699–8702.
23. T. Xie,#G.-Q. Wang,#Y.-W. Wang, W. Rao, H. Xu, S. Li,* Z.-L. Shen,*X.-Q. Chu,* Selective Quadruple C(sp3)-F Functionalization of Polyfluoroalkyl Ketones.iScience2020,23, 101259.
22. S.-W. Zhao, S.-Z. Cai, M.-L. Wang, W. Rao, H. Xu, L. Zhang,X.-Q. Chu,* Z.-L. Shen,* Selective C(sp3)-H Functionalization of Alkyl Esters withN-/S-/O-Nucleophiles Using Perfluoroalkyl Iodide as Oxidant.Adv. Synth. Catal.2020,362, 3388–3394.
21.X.-Q. Chu, D. Ge, M.-L. Wang, W. Rao,T.-P. Loh,*Z.-L. Shen,*Chemo- and Regioselective Ring Construction Driven by Visible-Light Photoredox Catalysis: An Access to Fluoroalkylated Oxazolidines Featuring an All-Substituted Carbon Stereocenter.Adv. Synth. Catal.2019, 361,4082–4090.
20.X.-Q. Chu,Z.-L. Shen,* T.-P. Loh,* Regioselective (Hetero)aryl C-H Thianthrenation and Late-Stage Transformations.Chem2019,5, 1025–1027.(Preview).
19.X.-Q. Chu,D. Ge, T.-P. Loh,* Z.-L. Shen,* Oxidant-Directed Chemoselective Sulfonylation and Sulfonyloximation of AlkenesviaCleaving C-S Bond in TosMIC.Org. Chem. Front.2019,6, 835–840. (IF 2020 = 5.281)
18.X.-Q. Chu,D. Ge, Z.-L. Shen,* T.-P. Loh,*Recent Advances in Radical-Initiated C(sp3)-H Bond OxidativeFunctionalization of Alkyl Nitriles.ACS Catal.2018,8, 258−271(Review, ACS Editors' Choice, ESI HighlyCitedPaper).
17.T. Xie, Y.-W. Zhang, L.-L. Liu, Z.-L. Shen, T.-P. Loh,*X.-Q. Chu.*Polycyclic Heteroaromatic Ring Construction Driven by Silver/Cobalt Co-Catalyzed Desulfonylative and Defluorinative Fragment-Recombination of Enol Nonaflates with Amidines.Chem. Commun.2018,54, 12722−12725.
16.X.-Q. Chu,T. Xie, L. Li, D. Ge, Z.-L. Shen,* T.-P. Loh,* Combining Fluoroalkylation and Defluorination to Enable Formal [3 + 2 + 1] Heteroannulation by Using Visible-Light Photoredox Organocatalysis.Org. Lett.2018,20, 2749–2752.
15.X.-Q. Chu,B.-Q. Cheng, Y.-W. Zhang, D. Ge, Z.-L. Shen,* T.-P. Loh,* Copper-Catalyzed Three-Component Cyclization of Amidines, Styrenes, and Fluoroalkyl Halides for the Synthesis of Modular Fluoroalkylated Pyrimidines.Chem. Commun.2018,54, 2615–2618(highlighted byX-MOL).
2013-2017 @Soochow University
14.X.-Q. Chu, W.-B. Cao,X.-P. Xu,*S.-J. Ji,*Iron Catalysis for Modular Pyrimidine Synthesis through β-Ammoniation/Cyclization of Saturated Carbonyl Compounds with Amidines.J. Org. Chem.2017,82, 1145–1154.
13.X.-Q. Chu,X.-P. Xu,*S.-J. Ji,*TBAI-Catalyzed/Water-Assisted Double C−S Bond Formations: An Efficient Approach to SulfidesviaMetal-Free Three-Component Reactions.Chem. Eur.–J.2016,22,14181–14185.
12.X.-Q. Chu,D. Liu, Z.-H. Xing, X.-P. Xu,*S.-J. Ji,*Palladium-Catalyzed Cyclization of Alkenes with Organohalides.Org. Lett.2016,18, 776–779.
11.X.-Q. Chu,Z.-H. Xing, H. Meng, X.-P. Xu,*S.-J. Ji,*Copper-Mediated Radical Alkylarylation of Unactivated Alkenes with Acetonitrile Leading to Fluorenes and Pyrroloindoles.Org. Chem. Front.2016,3, 165–169.
10.X.-Q. Chu,H. Meng, Y. Zi,X.-P. Xu,*S.-J. Ji,*Oxidative C(sp3)-H Functionalization of Acetonitrile and Alkanes with Allylic Alcohols under Metal-Free Conditions.Org. Chem. Front.2015,2, 216–220.
9.X.-Q. Chu,X.-P. Xu,*H. Meng,S.-J. Ji,*Synthesis of Functionalized Benzoxazines by Copper-Catalyzed C(sp3)–H Bond Functionalization of Acetonitrile with Olefinic Amides.RSC Adv.2015,5, 67829–67832.
8.X.-Q. Chu,H. Meng,X.-P. Xu,*S.-J. Ji,*One-Pot Synthesis of Allylic Sulfones, Ketosulfones, and Triflyl Allylic Alcohols from Domino Reactions of Allylic Alcohols with Sulfinic Acid under Metal-Free Conditions.Chem. Eur.–J.2015,21, 11359–11368(Front Cover & Hot Paper).
7.X.-Q. Chu,H. Meng, Y. Zi,X.-P. Xu,*S.-J. Ji,*Metal-Free Oxidative Radical Addition of Carbonyl Compounds toa,a-Diaryl Allylic Alcohols: Synthesis of Highly Functionalized Ketones.Chem. Eur.–J.2014,20, 17198–17206.
6.X.-Q. Chu,Y. Zi, H. Meng, X.-P. Xu,*S.-J. Ji,*Synthesis of 1,4-Dihydroquinoline Derivatives under Transition-Metal-Free Conditions and Their Diverse Applications.Org. Biomol. Chem.2014,12, 4243–4251.
5.X.-Q. Chu,H. Meng, Y. Zi,X.-P. Xu,*S.-J. Ji,*Metal-Free Oxidative Direct C(sp3)–H Bond Functionalization of Ethers witha,a-Diaryl Allylic Alcohols.Chem. Commun.2014,50, 9718–9721.
4.X.-Q. Chu,Y. Zi, H. Meng, X.-P. Xu,*S.-J. Ji,*Radical Phosphinylation ofa,a-Diaryl Allylic Alcohols with Concomitant 1,2-Aryl Migration.Chem. Commun.2014,50, 7642–7645.
3.X.-Q. Chu,Y. Zi, X.-M. Lu,S.-Y. Wang,*S.-J. Ji,*Intramolecular Pd-Catalyzed C-H Functionalization: Construction of Fused Tetracyclic Bis-Indole Alkaloid Analogues.Tetrahedron2014,70, 232–238.
2.X.-Q. Chu, S.-Y. Wang,*S.-J. Ji,*Recyclable NaHSO4Catalyzed Alkylation of Tertenamides with Indoles or Amines in Water: Facile Construction of Pharmaceutically Analogous Bis-Alkaloid Scaffolds.RSC Adv.2013,3, 8380–8387.
1.X.-Q. Chu,R. Jiang, Y. Fang, Z.-Y. Gu, H. Meng,S.-Y. Wang,*S.-J. Ji,*Acidic-Functionalized Ionic Liquid as an Efficient, Green, and Metal-Free Catalyst for Benzylation of Sulfur, Nitrogen, and Carbon Nucleophiles to Benzylic Alcohols.Tetrahedron2013,69, 1166–1174.
Book
1. S.-Y. Wang,X.-Q. Chu, Y.Fang, S.-J. Ji, Acetonitrile as Reagents in Organic Synthesis: Reactions and Applications,Solvents as Reagents in Organic Synthesis2018,355-375.
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