个人网页：http://www.researcherid.com/rid/H-7940-2016

教育和工作经历

2017年4月起 万博体育bet 化学与分子工程学院，教授

2014-2017年 英国布里斯托大学化学院，博士后

2010-2014年 西班牙加泰罗尼亚化学研究所（ICIQ），博士

2007-2010年 中国人民大学化学系，硕士

2002-2006年 兰州大学化学化工学院，学士

学术成绩

自2017年独立工作以来，研究方向集中于：以醇、糖、羧酸等廉价易得的基本化学品为原料，利用温和的电化学手段为关键步骤，高效合成有机功能分子及药物中间体。发表的主要基础研究工作包括：电化学氧化脱羧、脱氢、脱羟基构建Csp³–N、Csp³–Csp²键及其机理的DFT计算研究；电化学脱氧还原、脱氧负离子生成等方法；受邀撰写有机电化学合成领域综述3篇。在应用研究方面：将电化学脱羧策略应用于合成降血脂药物‘贝派地酸’，提高了总收率，获得中国专利授权1项；成功开发出治疗2型糖尿病肾脏病新药‘非奈利酮’起始物料的新方法，并实现了非奈利酮异构体的电化学回收策略，降低了成本。先后承担国家自然科学基金青年项目、江苏省自然科学基金青年项目、南京市留学人员科技创新择优资助等项目，并分别于2015年入选欧盟“玛丽居里学者计划”，2018年入选国家人社部“高层次留学人才回国资助计划”，2022年入选江苏省“科技副总”等人才项目。迄今已发表包括Science、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等论文40余篇，被引1500余次，其中ESI高被引论文2篇；申请发明专利7项，已授权3项。

研究方向

有机电化学合成、药物合成

代表性论文

24. Meng Li, Yue Tian, Kunhui Sun, Zhimin Xu, Lifang Tian*,Yahui Wang*, “Electrochemical deoxygenative arylation of aldehydes and ketones”Chem. Commun.2023,59, (37), 5587–5590.

23. Zhihui Wang, Xiaoqian Zhao, Hongyu Wang, Xiuyun Li, Zhimin Xu, Velayudham Ramadoss, Lifang Tian*,Yahui Wang*, “Dehydroxylative Arylation of Alcohols via Paired Electrolysis”Org. Lett.2022,24, (40), 7476–7481.

22. Kunhui Sun, Zhimin Xu, Velayudham Ramadoss, Lifang Tian*,Yahui Wang*, “Electrochemical deoxygenative reduction of ketones”Chem. Commun.2022,58, (79), 11155–11158.

21. Li-Li Zhu, Lifang Tian, Kunhui Sun, Yiwen Li, Guanglu Liu, Bin Cai, Hui Zhang*,Yahui Wang*, “N²-Selective β-Thioalkylation of Benzotriazoles with Alkenes”J. Org. Chem.2022,87, (19), 12963–12974. (Supplementary Cover).

20. Yue Zheng, Lifang Tian, Velayudham Ramadoss, Hui Zhang, Li-Li Zhu*,Yahui Wang*, “Recent Developments in N²-Selective Functionalizations of 1,2,3-Triazoles”Synthesis2022,54, (11), 2548–2560.

19. Hongyu Wang, Zhihui Wang, Guo Zhao, Velayudham Ramadoss, Lifang Tian*,Yahui Wang*, “Electrochemical Deoxygenative Barbier-Type Reaction”Org. Lett.2022,24, (20), 3668–3673.

18. Zhimin Xu, Yue Zheng, Lifang Tian*,Yahui Wang*, “Synthesis of Bempedoic Acid through Electrochemical Decarboxylation of Dialkylated Malonic Acid”Synthesis2021,53, (19), 3608–3612.

17. Haiwen Meng, Kunhui Sun, Zhimin Xu, Lifang Tian*,Yahui Wang*, “P^(III)-Assisted Electrochemical Access to Ureas via in situ Generation of Isocyanates from Hydroxamic Acids”Eur. J. Org. Chem.2021, (11), 1768–1772. (Highlighted by WileyChem公众号).

16. Shuo Wang, Zhimin Xu,Yahui Wang*, LifangTian*, “DFT investigation of the triphenylphosphine-assisted electrochemical dehydroxylative transformations”Mol. Catal.2021,504, (3), 111470.

15. Velayudham Ramadoss⁺, Yue Zheng⁺, Xiaoqing Shao, Lifang Tian*,Yahui Wang*, “Advances in Electrochemical Decarboxylative Transformation Reactions”Chem. Eur. J.2021,27, (10), 3213–3228.

14. Xiaoqing Shao, Yue Zheng, Velayudham Ramadoss, Lifang Tian*,Yahui Wang*, “Recent advances in P^III-assisted deoxygenative reactions under photochemical or electrochemical conditions”Org. Biomol. Chem.2020,18, (31), 5994–6005.

13. Yue Zheng, Xiaoqing Shao, Velayudham Ramadoss, Lifang Tian*,Yahui Wang*, “Recent Developments in Photochemical and Electrochemical Decarboxylative C(sp³)-N Bond Formation”Synthesis2020,52, (9), 1357–1368.(Thieme Chemistry高被引论文in 2020–2021).

12. Li-Li Zhu, Lifang Tian, Bin Cai, Guanglu Liu, Hui Zhang*,Yahui Wang*, “Diamine-mediated N²-selective β-selenoalkylation of triazoles with alkenes”Chem. Commun.2020,56, (20), 2979–2982. DOI: 10.1039/d0cc00601g, 2020-03-11, (Back Cover).

11. Zhimin Xu⁺, Yue Zheng⁺, Zhihui Wang, Xiaoqing Shao, Lifang Tian*,Yahui Wang*, “Triphenylphosphine-assisted dehydroxylative Csp³-N bond formation via electrochemical oxidation”Chem. Commun.2019,55, (100), 15089–15092.

10. Enhui Ji, Haiwen Meng, Yue Zheng, Velayudham Ramadoss,Yahui Wang*, “Copper-Catalyzed Stereospecific Hydroboration of Internal Allylic Alcohols”Eur. J. Org. Chem.2019, (44), 7367–7371.

9. Xiaoqing Shao⁺, Yue Zheng⁺, Lifang Tian⁺, Inmaculada Martín-Torres, Antonio M. Echavarren*,Yahui Wang*, “Decarboxylative Csp³-N Bond Formation by Electrochemical Oxidation of Amino Acids”Org. Lett.2019,21, (22), 9262–9267.

8. Xiaoqing Shao⁺, Lifang Tian⁺,Yahui Wang*, “C-N Coupling of Azoles or Imides with Carbocations Generated by Electrochemical Oxidation”Eur. J. Org. Chem.2019, (25), 4089–4094.

7. Li-Li Zhu*, Lifang Tian, Hui Zhang, Lina Xiao, Wen Luo, Bin Cai, Haifeng Wang, Chunjie Wang, Guanglu Liu, Chaoyu Pei,YahuiWang*, “Zinc-CatalysedN-Iodosuccinimide-Enabled Selective N²-Olefination of Benzotriazoles with Alkenes”Adv. Synth. Catal.2019,361, (5), 1117–1123.

6. Alexander Fawcett, Johan Pradeilles,Yahui Wang, Tatsuya Mutsuga, Eddie L. Myers, Varinder K. Aggarwal*, “Photoinduced decarboxylative borylation of carboxylic acids”Science2017,357, 283–286. (ESI Highly Cited Paper)

5.Yahui Wang, Adam Noble, Christopher Sandford, Varinder K. Aggarwal*, “Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans”Angew. Chem. Int. Ed.2017,56, 1810–1814. (IF=15.336)

4.Yahui Wang, Adam Noble, Eddie Myers, Varinder K. Aggarwal*, “Enantiospecific Alkynylation of Alkylboronic Esters”Angew. Chem. Int. Ed.2016,55, 4270–4274. (Highlighted by Synfacts)

3.Yahui Wang, Michael E. Muratore, Antonio M. Echavarren*, “Gold Carbene or Carbenoid, is there a Difference?”Chem. Eur. J.2015,21, 7332–7339. (ESI Highly Cited Paper)

2.Yahui Wang, Michael E. Muratore, Zhouting Rong, Antonio M. Echavarren*, “Formal (4+1) Cycloaddition of Methylencyclopropanes with 7-Aryl-1,3,5-cycloheptatrienes by Triple Gold(I) Catalysis”Angew. Chem. Int. Ed.2014,53, 14022–14026. (Hot Paper)

1.Yahui Wang, Paul R. McGonigal, Bart Herlé, Maria Besora, Antonio M. Echavarren*, “Gold(I) Carbenes by Retro-Buchner Reaction: Generation and Fate”J. Am. Chem. Soc.2014,136, 801–809.

王亚辉 教授

Email:ias_yhwang@njtech.edu.cn