毛建友教授

Email:ias_jymao@njtech.edu.cn

个人简介

2016-至今万博体育bet ，先进化学制造研究院，教授

2015-2016美国宾夕法尼亚大学化学系(Upenn)，博士后

2013-2015美国宾夕法尼亚大学，联合培养博士

2009-2015中国农业大学，应用化学系，硕士/博士

2005-2009河北农业大学，学士

研究方向

不对称催化，有机合成：

1.廉价金属催化的交叉偶联反应及其在药物及天然产物合成中的应用。

2.碱金属催化的弱酸性化合物C(sp³)-H键官能团化及应用。

3.药物、天然产物及生物活性分子全合成。

学术成绩

毛建友教授自回国加入万博体育bet 以来，一直从事于有机合成新方法开发（基于简单原料）、药物合成及新农药创制与合成（新合成方法应用）及高通量筛选（新合成方法优化及药物筛选）等方面的基础及应用研究。以第一作者与通讯作者在Nature Communications, Journal of American Chemical Society, Angewandte Chemie International Edition, Organic Letters等国际权威期刊发表论文40余篇。

目前主持国家自然基金面上项目及青年项目各一项和江苏省优秀青年基金及青年基金各一项。申请专利15项，授权7项：

（9）毛建友，凌搏，杨文军，一种β,β-二取代丙酸酯衍生物的合成方法，专利号：

201910996960.0。

（8）毛建友，关海星，一种邻位二胺类化合物的合成方法，专利号：201910955869.4。

（7）毛建友，徐鑫宇，王志婷，刘国晴，一种2-取代吲哚类化合物的合成方法，专利号：201910013285.5

（6）边庆花；钟江春；毛建友；郑冰；刘飞鹏；王敏；李硕宁，一种不对称催化合成（S）-2-芳基丙酸酯的方法，专利号：Zl 2014 1 0023042.7

（5）钟江春；边庆花；毛建友；刘飞鹏；郑冰；王敏；武林；杨燕青，一种不对称催化合成（S）-芳姜黄酮的新方法，专利号：Zl 2014 1 0023128.X

（4）钟江春；边庆花；毛建友；刘飞鹏；郑冰；李硕宁；武林，不对称催化合成（S）-非诺洛芬的方法，专利号：Zl 2014 1 0023139.8

（3）钟江春；李志愿；郑冰；毛建友；郭红超；王敏，一种高光学活性对映体合成海洋天然产物的方法，专利号：Zl 2010 1 0552418.5

（2）钟江春；李志愿；郑冰；毛建友；郭红超；王敏，一种手性环丙烷氨基醇配体化合物及其制备与应用，专利号：Zl 2010 1 0613074.4

（1）边庆花；钟江春；王敏；郑冰；刘飞鹏；毛建友；杨燕青，不对称催化合成（S）-萘普生的方法，专利号：Zl 2014 1 0023026.8

代表性论文：

39Ning Cui, Tingzhi Lin, Yan-En Wang, Jian Wu, Yuheng Han, Xinyang Xu, Fei Xue, Dan Xiong, Patrick J. Walsh*, and Jianyou Mao*Nickel-Catalyzed Reductive Coupling of γ-Metallated Ketones with Unactivated Alkyl Bromides.Organic Letters/2022, 24, 3987-3992.

38Tingzhi Lin, Pengcheng Qian, Yan-En Wang, Mingjie Ou, Ning Cui, Yu Ye, Rui Hua, Dan Xiong, Fei Xue, Patrick Joseph Walsh, Jianyou Mao. Palladium-Catalyzed Carbonylative Cross-Coupling of Aryl Iodides and Alkenyl Bromides with Benzyl Halides under Reductive Conditions.Asian Journal of Organic Chemistry. 2022, DOI: 10.1002/ajoc.202200243.

37Qianqian Lu, Haixing Guan, Yan-En Wang, Dan Xiong, Tingzhi Lin , Fei Xue , Jianyou Mao . Nickel/Photoredox-Catalyzed Enantioselective Reductive Cross-Coupling between Vinyl Bromides and Benzyl Chlorides.J. Org. Chem. 2022, 87, 12, 8048–805.

36.Chen, S.; Tan, J.; Xiong, D.; Shang, Y.; Mao, J.; Walsh, P. J., Palladium-catalyzed enantioselective (2-naphthyl)methylation of azaarylmethyl amines.Org. Chem. Front.2022Org. Chem. Front.2022,DOI：10.1039/d2qo00273f

35.Xu, X.; Ou, M.; Wang, Y.-E.; Lin, T.; Xiong, D.; Xue, F.; Walsh, P. J.;Mao, J.,*Alkali-amide controlled selective synthesis of 7-azaindole and 7-azaindoline through domino reactions of 2-fluoro-3-methylpyridine and aldehydes.Org. Chem. Front.2022,DOI：.10.1039/d2qo00339b

34.Yan-En Wang, Dongchen Yang, Dai, L. Jingqian Huo, Lai Chen, Zhanhai Kang,Jianyou Mao,*Jinlin Zhang*. Design, Synthesis, Herbicidal Activity, and Molecular Docking Study of 2-Thioether-5-(Thienyl/Pyridyl)-1,3,4-Oxadiazoles as Potent Transketolase InhibitorsJ. Agric. Food Chem.202270, 2510.

33.Gu, Y.; Zhang, Z.; Wang, Y.-E.; Dai, Z.; Yuan, Y.; Xiong, D.; Li, J.;, Patrick J. Walsh* andJianyou Mao,*Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+ System.J. Org. Chem.2022,87, 406.

32.Qian, Pengcheng, Guan, Haixing, Lu, Qianqian, Patrick J. Walsh, Mao, Jianyou* Catalytic Enantioselective Reductive Domino Alkyl Arylation of Acrylates via Nickel/Photoredox Catalysis.Nat. Commun.2021. 12.6613.Highlight in Synfacts: Snfacts 2022, 18(02). 0156.

31.Yan-En Wang, Dongchen Yang, Jingqian Huo, Lai Chen, Zhanhai Kang, Jianyou Mao,* Jinlin Zhang*. Design, Synthesis and Herbicidal Activity of Thioether Containing 1,2,4-Triazole Schiff Bases as Transketolase Inhibitors.J. Agric. Food Chem.202169,11773-11780.

30.Lai Chen, Jing-Qian Huo, He-Long Si, Xin-Yu Xu, Song Kou, Jianyou Mao,* Jin-Lin Zhang,* One-Pot Synthesis of N-H Free Pyrroles with Aldehydes and Alkynes.Org. Lett.2021, 23, 4348-4352. (SCI一区，IF=6.099).

29.Lin, Tingzhi, Qian, Pengcheng, Wang, Yan-En, Ou, Mingjie, Jiang, Long, Zhu, Chen, Xu, Yuchuan, Xiong, Dan,Mao, Jianyou*Palladium-Catalyzed Direct Arylation of 2-Pyridylmethyl Silanes with Aryl BromidesOrg. Lett.2021, DOI:10.1021/acs.orglett.1c00677.(SCI一区，IF=6.099)

28.Shuguang Chen, Langxuan Yang, Yongjia Shang,Jianyou Mao*, Patrick J. Walsh*, Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines,Org. Lett.2021,23, 1594-1599.(SCI一区，IF= 6.099)

27.Bo Ling, Wenjun Yang, Yan-En Wang, andJianyou Mao*, Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Vinyl Bromides to Enals, Org. Lett. 2020, 22, 9603–9608.(SCI一区，IF= 6.099)

26.Tingzhi Lin, Yuanyun Gu, Pengcheng Qian,Haixing Guan, Patrick J. Walsh* andJianyou Mao,*Nickel-Catalyzed Reductive Coupling of Homoenolates and Their Higher Homologues with Unactivated Alkyl Bromides.Nat. Commun.2020,11, 5638..(IF = 12.353，一区).Highlight in Synfacts: Synfacts 2021, 17 (02), 0166; Organic Chemistry Portal:https://www.organic-chemistry.org/Highlights/2021/26April.shtm; CBG:https://www.chembeango.com/zixun/53854;

25.Guan, H.; Zhang, Q.; Walsh, P. J.;Mao, J.,*Nickel/Photoredox-Catalyzed Asymmetric Reductive Cross-Coupling of Racemic α-Chloro Esters with Aryl Iodides.Angew. Chem., Int. Ed.2020,59, 5172.

24.Wenjun Yang, Bo Ling, Bowen Hu, Haolin Yin,Jianyou Mao,*and Patrick J. Walsh*,Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Aryl Iodides to Enals.Angew. Chem., Int. Ed.2019，DOI:10.1002/anie.201912584.(SCI一区，IF=12.257)

23.Jianyou Mao,*Zhiting Wang, Xinyu Xu, Guoqing Liu, Runsheng Jiang, Haixing Guan, Zhipeng Zheng, Patrick J. Walsh*Synthesis of indoles via domino reaction of 2-fluorotoluenes and nitriles.Angew. Chem., Int. Ed.2019，58,11033-11038.(SCI一区，IF=12.257)

22.Liu Guoqing, Walsh Patrick J.*,Mao Jianyou*.Alkaline-Metal-Catalyzed One-Pot Aminobenzylation of Aldehydes with ToluenesOrg. Lett.2019，21,8514-8518.(SCI一区，IF= 6.555)

21.Guan Haixing, Cao Xianzhong, Walsh Patrick J.*,Mao Jianyou*.One-Pot Aminoalkylation of Aldehydes: Diastereoselective Synthesis of Vicinal Diamines with AzaarylmethylaminesOrg. Lett.2019，21, 8679−8683.(SCI一区，IF= 6.555)

20.Shi, X.; Zhou, Y.; Liu, F.;Mao, J.; Zhang, Y.; Shan, T., Modeling of chiral gas chromatographic separation of alkyl and cycloalkyl 2-bromopropionates using cyclodextrin derivatives as stationary phases.J. Chromatogr. A2019,1596, 161.

19.Wang, H.; Chen, S.; Liu, G.; Guan, H.; Zhong, D.; Cai, J.; Zheng, Z.;Mao, J.*; Walsh, P. J.*, Synthesis of Diaryl Selenides via Palladium-Catalyzed Debenzylative Cross-Coupling of Aryl Benzyl Selenides with Aryl Bromides.Organometallics2018,37, 4086.(SCI二区，IF = 4.1)

18.Wang, Z.; Zheng, Z.; Xu, X.;Mao, J.*; Walsh, P. J.*One-pot aminobenzylation of aldehydes with toluenes.Nat. Commun.2018,9,3365-3373.(SCI一区，IF = 12.353)

17.Mao, J.*; Zhang, J.; Zhang, S.; Walsh, P. J.*NIXANTPHOS: a highly active ligand for palladium catalyzed Buchwald-Hartwig amination of unactivated aryl chloridesDalton Trans.2018,47, 8690.(SCI二区，IF = 4.099)

16.Lin, T.; Mi, J.; Song, L.; Gan, J.; Luo, P.;Mao, J.*; Walsh, P. J.*Nickel-Catalyzed Desymmetrizing Cross-Electrophile Coupling of Cyclic Meso-Anhydrides.Org. Lett.2018,20, 1191.(SCI一区，IF = 6.579)

15.Jia, T.; Zhang, M.; McCollom, S. P.; Bellomo, A.; Montel, S.;Mao, J.; Dreher, S. D.; Welch, C. J.; Regalado, E. L.; Williamson, R. T.; Manor, B. C.; Tomson, N. C.; Walsh, P. J.J. Am. Chem. Soc.2017,139, 8337.(SCI一区，IF = 13.858)

14.Zhang, S.; Kim, B.-S.; Wu, C.;Mao, J.*; Walsh, P. J.*Palladium-catalysed synthesis of triaryl(heteroaryl)methanes.Nat. Commun.2017,8, 14641.(SCI一区，IF=12.353)

Before Nanjing Tech

13.Mao, J.; Zhong, J.; Wang, B.; Jin, J.; Li, S.; Gao, Z.; Yang, H.; Bian, Q*. Synthesis of panaxytriol and its stereoisomers as potential antitumor drugs.Tetrahedron Asymmetry2016,27, 330.

12.Shi, X.; Liu, F.;Mao, J.The CGC enantiomer separation of 2-arylcarboxylic acid esters by using β-cyclodextrin derivatives as chiral stationary phasesAnal. Chim. Acta.2016,912, 156.

11.Mao, J.;Zhang,J.;Jiang,H.;Bellomo, A.;Zhang,M.;Gao,Z.;Dreher,S.D.; Walsh, P. J.:Palladium-Catalyzed Asymmetric Allylic Alkylations with TolueneDerivatives as Pronucleophiless,Angew. Chem., Int. Ed.2016,55, 2526.(SCI一区，IF = 11.709)

10.Mao, J.;Li,S.;Zhong,J.; Wang,B.;Jin,J.;Gao,Z.;Yang,H.; Bian, Q.:Total synthesis of panaxydol and its stereoisomers as potentialanticancer agents,Tetrahedron: Asymmetry,2016,27,69.

9.Sha,S.; Jiang,H.;Mao,J.;Bellomo, A.; Jeong, S. A.;Walsh, P. J.:Nickel-Catalyzed Allylic Alkylation with Diarylmethane Pronucleophiles: Reaction Development and Mechanistic Insights,Angew. Chem., Int. Ed.,2016,55,1070.

8.Liu,F.;Zhong,J.;Li,S.;Li, M.; Wu, L.;Wang, Q.;Mao,J.;Liu, S.; Zheng, B.; Wang, M.;Bian, Q.:Total Syntheses of (R)-Strongylodiols C and D,J. Nat. Prod,2016,79,244.

7.Mao, J.; Eberle, K.; Zhang, J.; Rodríguez-Escrich, C.; Xi, Z.; Pericàs, M. A.; Walsh, P. J.:Synthesis of Triarylmethanols via Tandem Arylation/Oxidation of Diarylmethanes,Tetrahedron Lett.2015,56, 3604.

6.Mao, J.; Liu, F.; Wang, M.; Wu, L.; Zheng, B.; Liu, S.; Zhong, J.; Bian, Q.; Walsh, P. J.:Cobalt-Bisoxazoline-Catalyzed Asymmetric Kumada Cross-Coupling of Racemic α-Bromo Esters with Aryl Grignard Reagents,J. Am. Chem. Soc.2014,136, 17662.(SCI一区，IF=13.858)

5.Mao, J.; Jia, T.; Frensch, G.; Walsh, P. J.:Palladium-Catalyzed Debenzylative Cross-Coupling of Aryl Benzyl Sulfides with Aryl Bromides: Synthesis of Diaryl Sulfides,Org. Lett,2014,16, 5304.(SCI一区，IF=6.579)

4.Mao, J.; Nie, X.; Wang, M.; Wang, Q.; Zheng, B.; Bian, Q.; Zhong, J.:Catalytic Asymmetric Nitroaldol (Henry) Reactions with Copper(II)/Cyclopropane-Based Bisoxazoline Complexes,Tetrahedron: Asymmetry,2012,23, 965.

3.Zheng, B.; Li, S.;Mao, J.; Wang, B.; Bian, Q.; Liu, S.; Zhong, J.; Guo, H.; Wang, M.:Highly Enantioselective Addition of 1,3-Diynes to Aldehydes Catalyzed by a Zinc–Amino Alcohol Complex,Chem. Eur. J.2012,18, 9208.

2.Li, Z.-Y.; Wang, M.; Bian, Q.-H.; Zheng, B.;Mao, J.; Li, S.-N.; Liu, S.-Z.; Wang, M.-A.; Zhong, J.-C.; Guo, H.-C.:Highly Enantioselective Addition of Trimethylsilylacetylene to Aldehydes Catalyzed by a Zinc-Amino-Alcohol Complex,Chem. Eur. J.2011, 17, 5782.

1.Zheng, B.; Wang, M.; Li, Z.; Bian, Q.;Mao, J.; Li, S.; Liu, S.; Wang, M.; Zhong, J.; Guo, H.:Asymmetric Henry Reaction Catalyzed by a Zn-Amino Alcohol System,Tetrahedron: Asymmetry2011,22, 1156.