Visible-light-initiated regio- & stereoselective C(sp²)–H phosphorylation of enamides under transition-metal-free conditions

Ji-Yu Tao,^†aQing-Hong Zhang,^†aTong-Hao Zhu,^†a,dXin-Wen Xu,^†aKun Ni,^aQiao Zhao,^aZheng-Bao Qin,^aYu Zhang,^bLili Zhao,^aand Kai Zhao^*a,c

^aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China. E-mail: ias_kzhao@njtech.edu.cn

^bCollege of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

^cGuangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China

^dInstitute of Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China

Abstract:A visible-light-induced stereo- and regioselective phosphorylation reaction of enamides with phosphine oxides has been disclosed, delivering synthetically and pharmaceutically appealing β-phosphorylated enamides with broad substrate scopes and excellent functional group tolerance under transition-metal-free conditions.

Org. Chem. Front.,2022, 9,6540−6546.(2021年影响因子:5.456).

论文链接：https://doi.org/10.1039/D2QO01304E